Amorphous cefuroxime axetil and preparation process therefore
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United States of America Patent
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Mar 24, 2009
Grant Date -
Jan 26, 2006
app pub date -
Jul 22, 2005
filing date -
Jul 22, 2004
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Abstract
A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the cefuroxime axetil in an amorphous form; particularly, the amorphous ultrafine or even nanosized cefuroxime axetil with a controllable particle size and a narrow particle size distribution. The cefuroxime axetil according to the invention can used to enhance bioavailability, since it is in an amorphous form and has a controllable particle size and a narrow particle size distribution.
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