Detection of colon or breast cancer by measuring TTK polynucleotide expression
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United States of America Patent
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Mar 10, 2009
Grant Date -
Mar 17, 2005
app pub date -
Sep 27, 2004
filing date -
Feb 21, 2001
priority date (Note) -
Expired
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Abstract
The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.
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