Taxane derivatives functionalized at the 14-position and a process for the preparation thereof
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United States of America Patent
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Mar 3, 2009
Grant Date -
Jun 8, 2006
app pub date -
Sep 5, 2003
filing date -
Sep 10, 2002
priority date (Note) -
Expired
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Abstract
A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described.
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