Non-racemic mixtures of (S) and (R) enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide; related processes and pharmaceutical compositions
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United States of America Patent
Stats
-
Feb 24, 2009
Grant Date -
Oct 21, 2004
app pub date -
Oct 8, 2002
filing date -
Oct 10, 2001
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention describes a method of separation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide. Another object of the present invention refers to the enantiomeric manipulation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to achiever compounds and pharmaceutical compositions presenting diverse enantiomeric excesses of (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to quantify and determine the participation of (R)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide in the anesthetic and cardiotoxic effects. These compounds and compositions enantiomerically manipulated demonstrate to present a significant improvement in itsanesthetic properties, presenting a cardiotoxic profile equivalent to pure enantiomer, a (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide.
First Claim
Other Claims data not available
Family
International Classification(s)
- 2002 Application Filing Year
- A61K Class
- 10774 Applications Filed
- 3504 Patents Issued To-Date
- 32.53 % Issued To-Date
