Process for the preparation of hypoallergenic mosaic antigens
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United States of America Patent
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Feb 17, 2009
Grant Date -
Nov 23, 2006
app pub date -
Dec 18, 2003
filing date -
Jan 21, 2003
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Abstract
A process for the preparation of an hypoallergenic mosaic antigen derived from an allergen is disclosed whereby a) in a first step the allergen is split into at least two parts and the IgE reactivity of each part is determined and b) in a second step those parts of the allergen which have no detectable IgE reaction are combined to a mosaic antigen which comprises the amino acids of the allergen but the order of the amino acids of the mosaic antigen is different from that of the naturally occurring allergen.
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