Altered insulin-like growth factor binding proteins
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United States of America Patent
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Feb 10, 2009
Grant Date -
Jul 13, 2006
app pub date -
Jul 11, 2003
filing date -
Jul 12, 2002
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Abstract
Altered IGFBPs are able to bind IGF, but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and to two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by use of the altered IGFBPs.
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