7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors

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United States of America Patent

PATENT NO 7488724
APP PUB NO 20060074065A1
SERIAL NO

11126061

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides compounds of formula (I):and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula (I), and intermediates useful for the synthesis of compounds of formula (I).

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Patent Owner(s)

Patent OwnerAddress
SOUTHERN METHODIST UNIVERSITY FOUNDATION FOR RESEARCH6425 BOAZ LANE P O BOX 750132 DALLAS TX 75205

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buynak, John D Dallas, US 23 104
Vogeti, Lakshminarayana Dallas, US 27 425

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