Non-glycosidic and non-peptidic inhibitors of selectin, and the use thereof
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United States of America Patent
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Feb 3, 2009
Grant Date -
Nov 29, 2007
app pub date -
Jul 26, 2005
filing date -
Jul 26, 2004
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Expired
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Abstract
A new class of non-glycosidic and non-peptidic inhibitors of selectins with low molecular weight according to the general formula 1is described, as well as methods for their production. These compounds represent a new class of non-toxic, in vivo anti-inflammatory effective inhibitors of selectins, and do not exhibit the disadvantages of the glycosidic inhibitor complexes, and are furthermore more potent in vitro, compared to the known drug bimosiamose. Furthermore, medicaments containing the compounds and their uses in the treatment of diseases are described.
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