Stereoselective synthesis of β-nucleosides
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United States of America Patent
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Feb 3, 2009
Grant Date -
Jan 18, 2007
app pub date -
May 2, 2006
filing date -
May 2, 2005
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Abstract
This invention relates to a process for stereoselectively preparing a nucleoside of the following formula:, and B are defined herein. The process includes reacting a furanose compound with a nucleobase in the presence of a halide salt. Also disclosed is another process for stereoselectively synthesizing an intermediate that can be used to make the starting compound in the first-mentioned process.
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