Medicinal composition
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United States of America Patent
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Feb 3, 2009
Grant Date -
Oct 27, 2005
app pub date -
Sep 12, 2002
filing date -
Sep 12, 2002
priority date (Note) -
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Abstract
The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pyrrolidinyl]benz- amide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidi- nyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT.sub.4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
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