Hepatocellular carcinoma specific promoter and uses thereof

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United States of America Patent

PATENT NO 7482156
SERIAL NO

10947812

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for treating neoplasia.

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Patent Owner(s)

  • CELL GENESYS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arroyo, Trini Palo Alto , US 1 13
Li, Yuanhao Palo Alto , US 17 191

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