Methods and compositions for activating VEGF-D and VEGF-C
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United States of America Patent
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Jan 20, 2009
Grant Date -
Dec 22, 2005
app pub date -
Jul 21, 2003
filing date -
Jul 23, 2002
priority date (Note) -
Expired
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Abstract
Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a phamarceutical compositions comprising plasmin. Also disclosed are methods for screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-C/D, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
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