Method for modulating, regulating and/or stabilizing angiogenesis
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United States of America Patent
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Jan 13, 2009
Grant Date -
Nov 24, 2005
app pub date -
Mar 8, 2005
filing date -
Mar 8, 2004
priority date (Note) -
Expired
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Abstract
A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in need thereof, in which the PDGF-D level or activity or both in the mammal are modulated or increased. In preferred embodiments, an active PDGF-D polypeptide, or a polynucleotide encoding an active PDGF-D is administered to the mammal, preferably at a location where angiogenesis modulation or stabilization is desired. The PDGF-D is advantageously co-administered with an angiogenic growth factor, such as a member of the VEGF family of growth factors, in particular VEGF-E. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.
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