Methods to engineer stratified cartilage tissue
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United States of America Patent
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Jan 13, 2009
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N/A
app pub date -
Sep 13, 2002
filing date -
Sep 15, 2001
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Expired
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Abstract
The present invention is directed to a cultured, stratified cartilage tissue that comprises a tissue-engineered, cohesive cartilage construct comprised of two or more cartilage layers, wherein each cartilage layer comprises chondrogenic cells having a chondrocytic phenotype corresponding to chondrocytes present in: a superficial-tangential zone of natural cartilage; a middle-transitional zone of natural cartilage; a deep-radial zone of natural cartilage; or a calcified cartilage zone of natural cartilage.
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