Tramadol recovery process
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United States of America Patent
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Dec 30, 2008
Grant Date -
May 17, 2007
app pub date -
Nov 13, 2006
filing date -
Nov 14, 2005
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis tramadol acid salt from the trans tramadol to obtain a purified cis tramadol acid salt; and optionally converting the cis tramadol acid salt to cis tramadol or to a pharmaceutically active salt thereof.
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