Adenosine A3 receptor modulators

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United States of America Patent

PATENT NO 7470698
APP PUB NO 20070249641A1
SERIAL NO

11774784

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The compounds of the following formula: ##STR00001## wherein R, R.sup.2, R.sup.3 and A have the meanings given in the specification, are endowed with selective A.sub.3 adenosine receptor antagonist activity. These compounds can be used in a pharmaceutical composition to treat disorders caused by excessive activation of the A.sub.3 receptor, or can be used in a diagnostic application to determine the relative binding of other compounds to the A.sub.3 receptor. The compounds can be labeled, for example with fluorescent or radiolabels, and the labels used in vivo or in vitro to determine the presence of tumor cells which possess a high concentration of adenosine A.sub.3 receptors.

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Patent Owner(s)

Patent OwnerAddress
KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT INC7001 WESTON PARKWAY SUITE 300 CARY NC 27513

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baraldi, Pier Giovanni Ferrara, IT 50 262
Borea, Pier Andrea Ferrara, IT 24 101

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