Delivery of superoxide dismutase to neuronal cells
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United States of America Patent
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Dec 30, 2008
Grant Date -
Nov 17, 2005
app pub date -
Feb 22, 2005
filing date -
Nov 5, 1998
priority date (Note) -
Expired
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Abstract
A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.
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