Methods for identifying ligands using competitive binding .sup.1H NMR experiments
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Dec 30, 2008
Grant Date -
Apr 15, 2004
app pub date -
Jun 5, 2003
filing date -
Jun 5, 2002
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a 1D .sup.1H nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a plurality of test samples, each test sample including at least one test compound; collecting a 1D .sup.1H nuclear magnetic resonance spectrum of the reference compound in the presence of each test sample and the target molecule; comparing the spectrum of the reference compound in the presence of the target molecule to the spectrum of the reference compound in the presence of each test sample and the target molecule to determine a change in one or more of the reference compound resonances; and identifying at least one test compound that interacts with the target molecule, wherein the test compound displaces the reference compound.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully