Phenyl substituted carboxylic acids
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United States of America Patent
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Dec 16, 2008
Grant Date -
Jun 8, 2006
app pub date -
Nov 18, 2005
filing date -
Nov 18, 2004
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed are compounds and pharmaceutically acceptable salts of formula (A): ##STR00001## which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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