Ansamycins having improved pharmacological and biological properties
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United States of America Patent
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Dec 16, 2008
Grant Date -
Dec 1, 2005
app pub date -
Feb 10, 2003
filing date -
Feb 8, 2002
priority date (Note) -
Expired
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Abstract
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
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