Vitamin D.sub.3-responsive sequences located 5'-upstream of p27/.sup.kip 1 gene and methods of screening for pharmaceutical agents using the sequences
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Dec 16, 2008
Grant Date -
N/A
app pub date -
Jul 21, 2000
filing date -
Jan 21, 2000
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A 44-bp region that confers vitamin D.sub.3-responsiveness to the human p27.sup.Kip1 promoter in the human p27.sup.Kip1 transcriptional regulatory mechanism was revealed. This region also conferred vitamin D.sub.3-responsiveness to a heterogenous promoter. Moreover, it was found that vitamin D.sub.3 enhances the binding between the CCAAT box existing in the region and the NF-Y protein and also the binding between the Sp1 sequence (also existing in the region) and the Sp1 protein, thus inducing human p27.sup.Kip1 transcription. Also revealed were methods of screening for pharmaceutical agents that regulate the expression of the p27.sup.Kip1 gene using these molecular mechanisms.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully