In situ or one-pot hydrogenation and reductive amination process
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United States of America Patent
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Dec 9, 2008
Grant Date -
May 29, 2008
app pub date -
Jan 23, 2007
filing date -
Nov 23, 2006
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Abstract
An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I): ##STR00001## and includes:a) the hydrogenation of a nitrile group of the compound of general formula (II): ##STR00002## in which R.sub.1 to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; andb) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
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