Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
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United States of America Patent
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Dec 2, 2008
Grant Date -
Sep 20, 2007
app pub date -
Oct 19, 2006
filing date -
Jan 27, 2004
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Abstract
A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.
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