Transgenic non-human mammals as models for human pathologies of stem cell origin
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United States of America Patent
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Nov 25, 2008
Grant Date -
Jun 15, 2006
app pub date -
Feb 1, 2006
filing date -
Nov 27, 2001
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Expired
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Abstract
Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1.sup.+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.
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