Process for the synthesis of substituted alpha-aminoindan derivatives
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United States of America Patent
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Nov 25, 2008
Grant Date -
Aug 16, 2007
app pub date -
Feb 21, 2005
filing date -
Feb 19, 2004
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Abstract
A process for the preparation of optically active substituted alpha-amino-indane derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step,in order to obtain optically active substituted alpha-amino-indane derivatives of formula (I).
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