Chromene-containing compounds with anti-tubulin and vascular targeting activity
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United States of America Patent
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Nov 25, 2008
Grant Date -
Nov 3, 2005
app pub date -
May 21, 2004
filing date -
May 3, 2004
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Abstract
Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
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