p21 peptides
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Nov 11, 2008
Grant Date -
Sep 9, 2004
app pub date -
May 19, 2003
filing date -
Nov 30, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.
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