Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients
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United States of America Patent
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Nov 11, 2008
Grant Date -
May 18, 2006
app pub date -
Oct 24, 2005
filing date -
Oct 22, 2004
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Abstract
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes--and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
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