Preparation of intermediates for acetycholinesterase inhibitors
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United States of America Patent
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Nov 4, 2008
Grant Date -
Feb 23, 2006
app pub date -
Jul 1, 2003
filing date -
Jul 1, 2003
priority date (Note) -
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Abstract
A simple, industrial process for the preparation of the intermediates of acetyl cholinesterase inhibitors is provided. Thus, for example, 5,6-dimethoxy-2-(4-pyridyl)methyl-1-indanone is hydrogenated using platinum oxide catalyst in the presence of hydrochloric acid under a pressure of 2 bars to give 4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, which is then converted to donepezil hydrochloride, an acetyl cholinesterase inhibitor.
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