Pyrazole-based HMG CoA reductase inhibitors
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United States of America Patent
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Nov 4, 2008
Grant Date -
May 25, 2006
app pub date -
Nov 18, 2005
filing date -
Nov 23, 2004
priority date (Note) -
Expired
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Abstract
Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase ('HMG CoA reductase') are described. Methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, Alzheimer's Disease, benign prostatic hypertrophy (BPH), diabetes and osteoporosis are also described.
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