Antibodies for preventing and treating attaching and effacing Escherichia coli (AEEC) associated diseases
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United States of America Patent
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Nov 4, 2008
Grant Date -
May 6, 2004
app pub date -
Mar 14, 2002
filing date -
Mar 15, 2001
priority date (Note) -
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Abstract
The present invention relates to antibodies immunologically specific for an attaching and effacing Escherichia coli (AEEC) virulence-associated protein, products, compositions and methods and to their use thereof in the prevention of an AEEC infection in a mammal. The antibody of the invention is immunologically specific for an AEEC virulence-associated protein and is capable of preventing an in vivo AEEC intestinal infection when administered to a mammal. The antibody of the invention is preferably useful for preventing the development of A/E intestinal lesions associated with the AEEC. This is achieved by preferably using IgY antibodies immunologically specific for one or more AEEC virulence-associated proteins, such as Eae, Tir, EspA and Paa.
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