Process for producing dioxolane nucleoside analogues
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United States of America Patent
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Oct 28, 2008
Grant Date -
Aug 23, 2007
app pub date -
Mar 5, 2007
filing date -
Jan 25, 2002
priority date (Note) -
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Abstract
The present invention relates to a process conducted in a single reaction vessel for producing a dioxolane nucleoside analogue of formula I or a pharmaceutically acceptable salt thereof; the process comprising the steps of adding a Lewis acid, a silylating agent and a non-silylated purine or pyrimidine base or an analogue thereof to a dioxolane of formula II. The invention also provides a process for producing a dioxolane compound of formula III; by reacting a dioxolane compound of formula IV in a suitable solvent in the presence of DIB and I.sub.2, using a suitable source of energy.
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