2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
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United States of America Patent
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Oct 28, 2008
Grant Date -
Sep 6, 2007
app pub date -
Nov 23, 2005
filing date -
Dec 17, 2004
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Abstract
The invention encompasses novel compounds of Formula I ##STR00001## or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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