Nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
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United States of America Patent
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Oct 28, 2008
Grant Date -
Jun 26, 2003
app pub date -
Dec 27, 2002
filing date -
Aug 7, 1998
priority date (Note) -
Expired
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Abstract
The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, or a Chp-specific immunogenic activity. The invention relates to all aspects of Chp, or homologs thereof, including assays for modulators, activators, ligands, etc.
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