Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin
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United States of America Patent
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Oct 14, 2008
Grant Date -
Aug 3, 2006
app pub date -
Jan 24, 2005
filing date -
Feb 18, 1994
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Expired
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Abstract
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.
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