Bicyclic and bridged nitrogen heterocycles
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United States of America Patent
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Oct 14, 2008
Grant Date -
Oct 20, 2005
app pub date -
Mar 2, 2005
filing date -
Mar 3, 2004
priority date (Note) -
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Abstract
Compounds are provided that act as potent modulators of one or more of the CCR1, CCR2 and CCR3 receptors. The compounds are generally fused-, spiro-or bridged-nitrogen heterocycles having an aryl and heteroaryl component and are useful in pharmaceutical compositions, methods for the treatment of CCR1-, CCR2- and/or CCR3-mediated diseases, and as controls in assays for the identification of competitive receptor antagonists for the above chemokine receptors.
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