Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
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United States of America Patent
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Oct 14, 2008
Grant Date -
Jul 14, 2005
app pub date -
Mar 8, 2005
filing date -
Jun 8, 2001
priority date (Note) -
Expired
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Abstract
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: ##STR00001## wherein Ar.sub.1, Ar.sub.3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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