High throughput screening method of drug for physiologically active protein
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United States of America Patent
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Oct 14, 2008
Grant Date -
Aug 10, 2006
app pub date -
Sep 8, 2004
filing date -
Sep 8, 2003
priority date (Note) -
Expired
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Abstract
The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use of a wheat embryo extract solution. The present inventors have strenuously studied to solve the matters above and finally completed the present invention by, in a system with the use of a wheat embryo, among cell-free protein synthesis means, constructing a synthesis system of a bioactive protein while sustaining its activities, and constructing a system for screening an inhibitor candidate to SARS 3CL.sup.pro, as an example using the synthesis system.
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