Tricyclic inhibitors of poly(ADP-ribose) polymerases
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United States of America Patent
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Sep 30, 2008
Grant Date -
Jan 12, 2006
app pub date -
Sep 6, 2005
filing date -
Jan 11, 1999
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Abstract
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. ##STR00001## As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.
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