Hepatitis-B viral variants with reduced susceptibility to nucleoside analogs and uses thereof
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United States of America Patent
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Sep 9, 2008
Grant Date -
Oct 19, 2006
app pub date -
Mar 15, 2006
filing date -
Mar 15, 2005
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Abstract
The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues, both in vivo and in vitro. More in particular, reverse transcriptase mutant rtA181S is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described.
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