Soluble neuropilin/growth factor receptor fusion proteins
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United States of America Patent
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Sep 2, 2008
Grant Date -
Jul 3, 2003
app pub date -
Nov 26, 2002
filing date -
Oct 19, 1998
priority date (Note) -
Expired
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Abstract
Complexes of a protein selected from the group consisting of VEGF-B.sub.167, VEGF-C, VEGF-D and processed VEGF-B.sub.186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B.sub.167, VEGF-C, VEGF-D or processed VEGF-B.sub.186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B.sub.167, VEGF-C, VEGF-D and/or processed VEGF-B.sub.186; and specific binding partners, e.g. antibodies, for such complexes.
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