Cell lines
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United States of America Patent
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Sep 2, 2008
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app pub date -
Nov 21, 2005
filing date -
Sep 30, 2004
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Abstract
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-unit of the telomerase construct.
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