Human schwannoma cell line
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United States of America Patent
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Sep 2, 2008
Grant Date -
Feb 28, 2008
app pub date -
Mar 3, 2003
filing date -
Mar 1, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7 genes. The cell line has a unique splice site mutation of the NF2 gene. The immortalized cell line is non-tumorigenic but has altered growth properties such as higher proliferation rate and independence of Schwann cell growth factors. Methods of using this unique cell line for pharmacologic screening are disclosed.
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