Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters
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United States of America Patent
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Sep 2, 2008
Grant Date -
May 26, 2005
app pub date -
May 10, 2004
filing date -
May 22, 2003
priority date (Note) -
Expired
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Abstract
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
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