EP.sub.4 receptor antagonists
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United States of America Patent
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Aug 26, 2008
Grant Date -
Jun 9, 2005
app pub date -
Oct 15, 2004
filing date -
Oct 16, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A compound of formula (I): ##STR00001## or a salt, solvate and chemically protected form thereof, wherein one of R.sup.2 and R.sup.5 is: (i) H or an optionally substituted C.sub.1-4 alkyl group; or (ii)an optionally substituted C.sub.5-7 aryl; and the other of R.sup.2 and R.sup.5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 R.sup.N is H or optionally substituted C.sub.1-4 alkyl R.sup.3 is either: (i) carboxy; (ii) a group of formula (II): ##STR00002## (iii) a group of formula (III): ##STR00003## wherein R is optionally substituted C.sub.1-7 alkyl, C.sub.5-20 aryl, or NR.sup.N3R.sup.N4, where R.sup.N3 and R.sup.N4 are independently selected from optionally substituted C.sub.1-4 alkyl; or (iv) tetrazol-5-yl.
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