HBM variants that modulate bone mass and lipid levels
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United States of America Patent
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Aug 26, 2008
Grant Date -
Mar 31, 2005
app pub date -
May 13, 2002
filing date -
May 11, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
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