Process for manufacture of 4-amino-hydroxybutylidene-1, 1-bisphosphonic acid and its salts
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United States of America Patent
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Aug 19, 2008
Grant Date -
Jun 28, 2007
app pub date -
Dec 27, 2006
filing date -
Dec 27, 2005
priority date (Note) -
Expired
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Abstract
The preset invention relates to a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt, such as sodium alendronate, from inexpensive and readily available pyrrolidone using phosphonating agents such as PCl.sub.3 in the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid, and pharmaceutical dosage forms of alendronic acid or pharmaceutically acceptable salts thereof.
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