Vaccine comprising a polynucleotide encoding an antigen recognized by a CD4.sup.+ helper T-cell and a polynucleotide encoding a tumor specific or associated antigen recognized by a CD8.sup.+ CTL
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United States of America Patent
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Aug 19, 2008
Grant Date -
Oct 7, 2004
app pub date -
Dec 23, 2003
filing date -
Jun 25, 2001
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Abstract
The present invention relates to a DNA vaccine for developing tumor-specific immunity. Specifically, the invention relates to a DNA vaccine comprising antigens recognized by CD4.sup.+ helper T cells and CD8.sup.+ cytotoxic T cells, respectively. Preferably, the antigen recognized by CD4.sup.+ helper T cells is a molecule identified by the SEREX method and that recognized by CD8.sup.+ cytotoxic T cells is a tumor-specific antigen, tumor-associated antigen or cell-associated antigen. Furthermore, so that the antigens recognized by CD4.sup.+ helper T cells and CD8.sup.+ CTL are expressed and presented on the same cell, the expression vectors preferably are immobilized on the same gold particle and administered into the cell by gene gun; however, this invention is not restricted thereto. The vaccine can also be used as a pharmaceutical agent.
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