Matched filtration with experimental noise determination for denoising, peak picking and quantitation in LC-MS
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United States of America Patent
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Aug 5, 2008
Grant Date -
Nov 24, 2005
app pub date -
Apr 11, 2003
filing date -
Apr 12, 2002
priority date (Note) -
Expired
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Abstract
An improved system and method of analyzing sample data that increases the reliability of peak (compound) detection and identification in the presence of chemical and/or random noise. The sample analysis system includes a compound-separating unit for separating constituent compounds in a sample mixture, a compound-analyzing unit for identifying and quantitating at least one of the separated compounds, and a computer for acquiring data from the compound-separating and compound-analyzing units, for generating a multi-dimensional data set incorporating the acquired data, for executing an algorithm for reducing noise in the data set and for detecting peaks (compounds) in the noise-reduced data set, and for identifying/quantitating the detected compounds.
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