Multivalent vaccine composition having increased stability of capsular polysaccharide
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United States of America Patent
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Jul 29, 2008
Grant Date -
Sep 2, 2004
app pub date -
Jul 31, 2002
filing date -
Aug 8, 2001
priority date (Note) -
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Abstract
A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more o-acetyl groups and which is not adsorbed with aluminum oxide due to the presence of a protecting compound which may be a phosphate, a citrate or a carbonate and which prevents the adsorption. The first valence can be any vaccine valence. In one particular embodiment, the vaccine composition contains (i) Hepatitis A valence, adsorbed on aluminum hydroxide and (ii) the typhoid fever valence formed by the polysaccharide Vi of the Salmonella typhi capsule.
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